Ein multinationaler Delphi-Konsens zur Beendigung der COVID

Nature volume 611, pages 332–345 (2022)Cite this article

232k Accesses

32 Citations

6405 Altmetric

Metrics details

Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic1,2. Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches1, while maintaining proven prevention measures using a vaccines-plus approach2 that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities3 in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

Pandemics have disrupted societies and impacted public health throughout human history4. Today, almost 3 years after SARS-CoV-2 was first identified and more than 1.5 years after the first vaccines became available, pandemic fatigue5 threatens to undercut our vigilance and the effectiveness of our responses to ongoing and new pandemic-related challenges. As of September 2022, more than 620 million cases of COVID-19 and over 6.5 million deaths have been reported6, although mortality estimates range as high as 20 million7,8. The healthcare for millions more people has been delayed, often as a result of overwhelmed health systems9,10,11,12. Highly transmissible variants continue to spread globally, while surveillance for variants of concern remains largely inadequate13,14,15. Reinfection risks are not fully understood. Low vaccination rates16 may compound the risk from waning immunity17,18. Long COVID has emerged as a serious chronic condition19,20,21 that represents a considerable burden of disease and still lacks adequate understanding and appropriate preventive or curative solutions. In addition to its direct health consequences, COVID-19 has disrupted economic activity, social interactions and political processes, affected civil liberties and interrupted education at all levels22,23,24,25,26. Although many governments and individuals no longer have the same level of concern as earlier in the pandemic27, many public health leaders, including members of this panel28, continue to regard COVID-19 as a persistent and dangerous health threat29,30,31.

Responses to the COVID-19 pandemic have been hindered by interrelated factors that include false information32, vaccine hesitancy33,34, inconsistent global coordination35, and the inequitable distribution of supplies36, vaccines37,38 and treatments39. Despite increased levels of trust in science during the pandemic23,40, there is information fatigue4 and waning compliance with those public health and social measures41,42,43 that remain in place, particularly those that affect daily lives44. Meanwhile, during periods of high community transmission, needs for services continue to exceed the capacity of many health systems45, which also are challenged by ongoing risks to the health of their workers46,47,48. Furthermore, long-standing social inequities have caused some populations to experience greater risk of COVID-19 infection, severe disease and death37. Many of these populations continue to have less access to COVID-19 vaccines37,49 and treatment39, as well as to resources to mitigate the mental health, social and economic consequences of the pandemic50,51,52.

Beneficial knowledge about COVID-19 aetiology, pathophysiology, prevention, vaccination, treatment and care has rapidly advanced through rigorous scientific, medical and public health inquiry, debate and collaboration53,54,55,56. Notwithstanding these advances, the responses of individual countries have been heterogeneous and often inadequate, in part because they lack coordination and clear goals.

To develop a global consensus regarding these ongoing problems, we carried out a Delphi study with a multidisciplinary, geographically diverse panel of 386 academic, health, non-governmental organization (NGO), government and other experts in COVID-19 response from 112 countries and territories (Table 1 and Methods). We achieved response rates of 85% in the second round (R2) and 82% and 81% in the third round (R3) surveys of the 41 statements and 57 recommendations, respectively. The mean levels of combined agreement (agree + somewhat agree) increased across the three rounds of the consensus statements (R1, 89%; R2, 90%; R3, 96%) and the two rounds of recommendations (R2, 93%; R3, 98%). The resulting consensus statements and recommendations (Fig. 1) can serve as a strong basis for decision-making to end COVID-19 as a public health threat, and permit a more durable resumption of social, cultural, religious, political, healthcare, economic and educational activities, with less burden on vulnerable populations.

Study methodology, including sample and data collection. Top, the iterative sampling approach used to generate a large, diverse Delphi panel (n = 386): four project co-chairs identified a core group of 40 academic, health, NGO, government and policy experts from 25 countries; the core group identified individuals with expertise in COVID-19; under-represented countries (that is, with fewer than one invitee) were identified and targeted through PubMed/Medline searches for authors of COVID-19 research studies in these countries. Bottom, the iterative digital data-collection process, including two survey rounds (R1 and R2) of draft statements; an online consensus meeting of the core group (Supplementary Discussion 3); one round of draft recommendations (R2); and a final survey round (R3) of the consensus statements and recommendations. Earlier rounds included text boxes for panellists to provide comments and suggest edits to individual statements (R1, R2) and recommendations (R2); the final statement and recommendations round (R3) allowed for overall comments at the end of each domain. For the final set of recommendations in R3, panellists ranked the top half in each of the six domains. RR, response rate.

This multidisciplinary and multinational consensus study yielded 41 statements (Tables 2 and 3) and 57 forward-looking recommendations (Tables 4–7) on ending COVID-19 as a threat to public health grouped into six domains. Although we suggest that policymakers and other interested stakeholders review and consider the entire study findings, for expediency, we break out the top 10 recommendations ranked by the panellists in Table 8.

The top three recommendations focus on whole-of-society1 action and maintaining, or in some cases returning, to a vaccines-plus approach2. First, to avoid the inefficiency and ineffectiveness of fragmented efforts, pandemic preparedness and response should adopt a whole-of-society strategy that includes multiple disciplines, sectors and actors. Second, going forward, whole-of-government approaches (such as interministry coordination) can identify, review and address resilience in health systems to make them more responsive to people's needs. Third, all countries should adopt a vaccines-plus approach, which includes a combination of COVID-19 vaccination, other prevention measures, treatment and financial incentives such as support measures. Infection rates tend to increase when governments discontinue social measures, including non-pharmaceutical interventions, regardless of the level of vaccination57,58.

The degree of consensus achieved for statements and recommendations, along with a ranking exercise in the final round, informed our synthesis of the study's findings into six cross-cutting themes (Box 1) to which we believe decision-makers should pay particular attention: (1) SARS-CoV-2 is still present among us—despite some governments moving on—requiring continued efforts and resources to save lives; (2) vaccines are an effective tool against COVID-19 but will not alone end COVID-19 as a public health threat; (3) multisectoral collaboration that centres on communities and fosters trust is needed; (4) responsive health systems are crucial for responding to the COVID-19 pandemic and require coordinated government support; (5) adverse forces challenge efforts to end the COVID-19 public health threat; and (6) none of us is safe until everyone is safe. For ease of review, we report the tophalf ranked recommendations within each domain (Extended Data Fig. 1).

SARS-CoV-2 still moves among us—despite some governments moving on—requiring continued efforts and resources to save lives. Reservoirs exist from which variants of concern may yet emerge104,105; possible endemicity45 does not necessarily mean lower disease severity106. Broad-based funding to develop long-lasting immunogenic vaccines must proceed concurrent with other prevention measures. The long-term impact of infection must be assessed, as long COVID has emerged as a chronic condition107,108,109,110.

Vaccines are an effective tool against COVID-19 but will not alone end COVID-19 as a public health threat. Vaccination as a sole pandemic response strategy has limitations due to immune escape111,112,113, waning immunity17,114,115, inequitable access34,116, vaccine hesitancy117,118,119,120 and the absence of immunization strategies121. A multifaceted public health vaccines-plus approach is needed, including testing, surveillance, treatment122, community engagement and implementation of social prevention measures (such as facemasks123,124, distancing and quarantine), structural interventions (such as ventilation and air filtration)2 and financial incentives (for example, support measures).

Multisectoral collaboration that centres on communities and fosters trust is needed. Ending COVID-19 as a public health threat requires whole-of-society and whole-of-government approaches engaging trusted community leaders and organizations, scientific experts, businesses, and other disciplines and sectors1,125. This expanded pool of collaborators can best address diverse needs regarding modes of access, communication, innovation and trust among different populations126,127.

Responsive health systems are crucial for responding to the COVID-19 pandemic and require coordinated government support. The persistent demand on health systems requires protecting the physical and mental wellbeing of healthcare workers; reducing economic barriers for equipment and treatment, including addressing supply-chain factors128; strengthening primary care; and adopting a comprehensive, intersectoral, multilevel approach to preparedness and response activities.

Adverse forces challenge efforts to end the COVID-19 public health threat. Counteract sovereign state actors who are openly antagonistic toward science and public health and other entities with vested interests that disseminate false information. Public health authorities should build trust in evidence-based communications and partner with those monitoring and holding accountable disseminators of false information129.

None of us is safe until everyone is safe. Pandemic inequities must end. This includes taking into account pre-existing social determinants of health, addressing access to affordable vaccines, tests, other supplies and treatment50,130, and paying special attention to the needs of vulnerable groups (such as older131,132 and immunocompromized133 individuals, children134 and healthcare workers48,135,136).

The Delphi process involves a review and revision methodology that can result in relatively greater agreement among statements and recommendations over successive survey rounds while also identifying areas of disagreement that may require special efforts going forward. In addition to its the four-point Likert agreement–disagreement response options available in this study, panellists could select ‘not qualified to respond’ for items that they perceived as falling outside their expertise (see the ‘Delphi expert panel member sample’ section in the Methods). Although our study reflects relatively few areas of disagreement, we believe that highlighting the key areas of disagreement may be instructive for decision-makers in their own prioritization processes addressing the COVID-19 pandemic.

Extended Data Table 1 presents the six recommendations reflecting 5% or greater disagreement (disagree + somewhat disagree). Of those six, only two recommendations had greater than 10% disagreement: 18% of panellists disagreed with the recommendation to consider further economic incentives to potentially address vaccine hesitancy (REC3.6) and 11% disagreed with the recommendation that providers adopt a syndromic approach to COVID-19 diagnosis in settings with lower access to testing (REC2.18). The remaining four recommendations broadly relate to the use of governmental regulatory and enforcement powers in disease control efforts.

For statements and recommendations with response rates of ‘agree’ alone (that is, not combined with ‘somewhat agree’) below 67%, we conducted bivariate analyses to examine potential associations with panellist demographics; six statements (STMT1.2, STMT1.3, STMT2.1, STMT2.3, STMT3.5, STMT6.6) and one recommendation (REC4.5) demonstrated significant differences. Respondents who disagreed were significantly more likely to work in low- and middle-income countries than in high-income countries (P < 0.05; Supplementary Discussion 2). Few differences in agreement were identified by sector or field of employment, except for STMT1.1, for which greater disagreement was identified among those working in the health policy/advocacy field, and for STMT1.3, for which the academic and public sectors evidenced greater disagreement than other sectors.

The following six domains summarize the main areas of agreement, with a particular focus on the recommendations. The quantitative results on agreement and disagreement for the statements and recommendations are reflected in the tables and are further illustrated in Supplementary Discussion 1.

Substantial combined agreement among the panellists (range, 88–100%) indicates that communication issues remain a key area of risk and opportunity for ending COVID-19 as a public health threat. Policymakers and public health agencies should take special care when communicating the causation of and continuing accountability for the pandemic (Tables 2 (STMT1.7) and 4 (REC1.1)). The lowest level of agreement in this domain (agree, 57%; combined agreement, 88%) was found for a statement about government accountability receiving less attention when unvaccinated individuals are blamed for the pandemic's continuation (Table 2 (STMT1.6)).

The panel focused primarily on the role of trust in government (Table 2 (STMT1.5)), the consequences of false information (Table 2 (STMT1.2, STMT1.3, STMT1.4)) and the rapid production of large volumes of new COVID-19-related information (Table 2 (STMT1.1)). That said, governments themselves may be a source of misinformation, for example, in the context of identifying transmission mechanisms (Table 6 (REC4.3)) and when stating that the COVID-19 pandemic has ended (Table 2 (STMT1.7)).

To counteract the infodemic and false information, governments should monitor false information (Table 4 (REC1.7)), expose networks of false information (Table 4 (REC1.9)) and consider holding publishers of false information liable (Table 4 (REC1.10)). Furthermore, public health professionals and other authorities should use clear, culturally responsive messaging to combat false information (Table 4 (REC1.3)). In parallel, social media companies should implement controls that reduce the publication and dissemination of false health information (Table 4 (REC1.8)).

Institutions and individuals should advance public trust by seeking training on building trust and developing trust-oriented communication strategies (Table 4 (REC1.4)), expanding collaboration with community leaders and the scientific community (Table 4 (REC1.1)), and working with individuals and organizations that have established trust in communities (Table 4 (REC1.2)). Using the preferred means of communication for different populations was unanimously recommended to further earn trust (Table 4 (REC1.1)).

Multidisciplinary research should assess the impact of the COVID-19 infodemic on health behaviours and outcomes (Table 4 (REC1.5)). Research funders should commission more reviews that synthesize, evaluate and disseminate COVID-19-related evidence to inform needed interventions (Table 4 (REC1.6)).

Health systems have experienced wide-ranging circumstances throughout the pandemic, from periods of relative calm to periods of near collapse. The broad agreement among panellists strongly suggests that, although many health systems will remain at risk of once again being overwhelmed, those risks can be mitigated. Certain sources of risk to health systems are essentially structural, such as the lack of implementation of an evidence-based, globally agreed-upon set of minimum COVID-19 pandemic response standards (Table 2 (STMT2.1)).

As noted above, health systems recommendations with respect to whole-of-society (Table 4 (REC2.5)) and whole-of-government approaches (for example, multiministry coordination) (Table 4 (REC2.6)) were among the most highly ranked by the panel.

As community transmission of SARS-CoV-2 continues to present a risk to health systems, particularly through variants of concern, extensive virological surveillance should be used (Table 5 (REC2.8)). Public health policies should take better account of the potential long-term impact of the unchecked spread of COVID-19 given the ongoing uncertainties about the prevalence, severity and duration of post-COVID-19 morbidity (long COVID) (Table 5 (REC2.9)). Member States should authorize the World Health Organization (WHO) to lead a large, inclusive, multistakeholder, global effort to provide public health and clinical targets pertaining to SARS-CoV-2 and COVID-19, with an emphasis on cases, vaccination, morbidity and mortality (Table 5 (REC2.17)).

Economic impacts, notably costs borne by consumers (Table 2 (STMT2.5)), create risks to health systems. To address these risks, structural and economic recommendations include removing economic barriers to SARS-CoV-2 tests, personal protective equipment, treatment and care (Table 4 (REC2.1)), supporting the development of regional manufacturing hubs for COVID-19 supplies, treatments and vaccines (Table 4 (REC2.2)), and considering legislative and regulatory reforms to address market failures (Table 5 (REC2.16)). Where access to PCR or antigen tests is limited, providers should consider adopting a syndromic approach (Table 5 (REC2.18)). Notably, REC2.18 is the health systems recommendation with the highest percentages of panellists disagreeing as well as panellists indicating ‘not qualified to respond’.

To reduce the burden on hospitals, the role of primary health care should be strengthened (Table 5 (REC2.10)), while health care workers’ physical, mental and social well-being should be supported (Table 4 (REC2.4)).

With respect to digital health, the recommendations encourage increasing investments in digital health infrastructure (Table 5 (REC2.13)), adapting user interfaces and experience to expand access, particularly for vulnerable groups (Table 4 (REC2.3)), and leveraging implementation science to determine which digital health solutions can be quickly scaled (Table 5 (REC2.12)).

With respect to procurement practices, engaging continuous improvement disciplines for intercountry procurement, pooling and supply-chain management was urged (Table 5 (REC2.11)). To best leverage community-based interventions and services, community-based organizations and students pursuing degrees in health-related fields should be engaged in providing COVID-19 education, testing and vaccination services (Table 5 (REC2.14)).

As social, political and economic sector risks continue to have spillover effects on health systems, key multisectoral indicators for systemic risks to health systems should be identified and assessed (Table 5 (REC2.7)).

Finally, health systems should identify and, where possible, reduce diagnostic, treatment and care backlogs for non-COVID-19-related medical conditions (Table 5 (REC2.15)).

Even assuming continued innovation of vaccines and interventions that reduce vaccine hesitancy, 97% of the panel agrees that vaccination alone is insufficient to end the COVID-19 pandemic as a public health threat (Table 2 (STMT3.6)). Thus, the panel places a strong emphasis on additional prevention measures, particularly, as noted above and in the ten highest-ranked recommendations (Table 8), for countries to adopt a vaccines-plus approach, as discussed in the next domain.

Regarding the key role of vaccines, the panel made a range of recommendations. Government, philanthropic and industry funding should invest in developing vaccines that provide long-lasting protection against multiple SARS-CoV-2 variants (Table 6 (REC3.4)). As waning immunity remains a risk, calculations for immunity should consider the time after the date of vaccination and/or infection and be regularly updated with new scientific evidence (Table 6 (REC3.5)).

Vaccine hesitancy, which ranges from delay to refusal despite availability of vaccine services, remains a major challenge (Table 2 (STMT3.3)). To reduce vaccine hesitancy and increase uptake, several interventions are recommended: engaging trusted local leaders and organizations in vaccination efforts (Table 6 (REC3.2)), providing information that clearly explains the efficacy and limitations of current vaccines (Table 6 (REC3.1)) and tailoring messages to address the underlying bases of various populations’ specific concerns through targeted public health communications (Table 6 (REC3.3)). Vaccine hesitancy may also be associated with false information, which is addressed in the communication domain above.

On the one hand, panellists largely agree that medical autonomy of individuals with decision-making ability extends to the right to make one's own decisions regarding vaccination (Table 2 (STMT3.2)). On the other hand, panellists also acknowledge that, when the risk of harm to others is sufficiently severe, governments may determine that the right of all individuals to good health overrides the autonomy of any one individual to choose not to be vaccinated (Table 2 (STMT3.1)). These statements reflect among the highest levels of combined disagreement (Table 2 (STMT3.1, 9%; STMT3.2, 16%)). Civil liberties implications are further discussed in the next domain.

As noted above, vaccination alone will not end COVID-19 as a public health threat (Table 2 (STMT3.6)) for all people. Infection rates tend to increase when governments discontinue social measures, including non-pharmaceutical interventions, regardless of the level of vaccination (Table 3 (STMT4.5)). Thus, all countries should adopt a vaccines-plus approach, including a combination of COVID-19 vaccination, other prevention measures, treatment and possibly financial incentives (Table 6 (REC4.5)).

Although the nature and vectors of SARS-CoV-2 transmission were not clearly understood early in the pandemic, current evidence guided the panellists to near-unanimous agreement that SARS-CoV-2 is an airborne virus that presents the highest risk of transmission in indoor areas with poor ventilation (Table 3 (STMT4.1)). Risk-related communications from all actors should clearly emphasize that transmission of SARS-CoV-2 is primarily caused by inhalation of the virus (Table 6 (REC4.3)). Considering the airborne nature of transmission, governments should regulate and incentivise structural prevention measures, such as ventilation and air filtration (Table 6 (REC4.1)), and high priority should be given to preventing SARS-CoV-2 transmission in the workplace, educational institutions and commercial centres (Table 6 (REC4.6)).

Mammal-to-mammal transmission represents a reservoir for future zoonotic variants (Table 3 (STMT4.3)). Thus, substantial virological surveillance based on whole-genome sequencing of positive samples in human and high-risk mammal populations is an essential component of the continued pandemic response and preparedness (Table 5 (REC2.8)).

National and international travel restrictions should be based on current scientific knowledge and prevailing transmission rates of all variants that consider relevant, health-based factors (Table 6 (REC4.4)). Measures that are no longer scientifically valid for COVID-19 prevention should be immediately removed from COVID-19 guidance and policy (Table 6 (REC4.2)). Going forward, governments should consider imposing broad restrictions on civil liberties only in the event of variants of concern presenting risk of high rates of transmission and severity, coupled with waning immunity or vaccine resistance (Table 6 (REC4.7)).

Panellists had substantially high agreement regarding all aspects of treatment and care, indicating that treatment will continue to be an area of major importance both for ending COVID-19 as a public health threat and for individual patient care. Notably, a statement addressing the risk of prioritizing treatment over prevention (Table 3 (STMT5.1)) had the highest level of combined disagreement (7%) for this domain.

With current public health policies reflecting greater tolerance for community transmission and increased rates of infection, research into COVID-19 must adapt and develop further evidence to understand the cumulative effect of COVID reinfection (Table 7 (REC5.4)). Research is needed to determine whether infection from distinct variants of SARS-CoV-2 is associated with significant differences in long-term morbidity (Table 3 (STMT5.4)). Additional research funding, particularly for long COVID, should be prioritized (Table 7 (REC5.6)), and multisectoral collaboration should accelerate new therapies across all stages of COVID-19 (Table 7 (REC5.2)). Moreover, global case definitions should be standardized (Table 7 (REC5.1)).

Echoing some statements and recommendations in the pandemic inequities domain (discussed below), clinical trials and longitudinal cohorts should be more inclusive and statistically representative regarding age, gender and vulnerable populations (Table 7 (REC5.3)).

The substantial agreement of the panellists suggests that addressing inequities remains a global challenge. Immediate efforts should be made to reduce vaccine wastage (Table 7 (REC6.8)), addressing the need for cold storage, transport and other infrastructure-based barriers in low-resource settings (Table 7 (REC6.4)), addressing the affordability of testing and treatment for people in all countries (Table 7 (REC6.2)), as well as accelerating efforts to distribute vaccines in low- and middle-income countries (Table 7 (REC6.10)).

Transfer agreements to increase production capacities in low- and middle-income countries should be expedited (Table 7 (REC6.6)). Pre-existing social and health inequities must be considered in pandemic preparedness and response going forward (Table 7 (REC6.7)). The findings call special attention to two vulnerable populations: children (Table 7 (REC6.5)) and those living within or fleeing from conflict zones (Table 7 (REC6.9)).

The pandemic has illustrated the risk of over-reliance on experts from a small number of disciplines (Table 3 (STMT6.8)), often excluding the expertise of community members (Table 4 (REC1.2)) and vulnerable groups (Table 3 (STMT6.7)). Instead, vulnerable groups should be sought out and actively engaged (Table 7 (REC6.3)). As noted in the communication domain, community leaders should also be engaged (Table 4 (REC1.1)). Multidisciplinary experts who understand local contexts should be included in developing national operational plans for ending COVID-19 as a public health threat (Table 7 (REC6.1)). COVID-19 tests and treatments should be affordable for all people in all countries (Table 7 (REC6.2)).

Wide-ranging pandemic control measures59,60,61,62 have not ended COVID-19 as a public health threat63,64,65,66,67,68. Although this study echoes some earlier findings—for example, the Independent Panel for Pandemic Preparedness and Response35, the European Union 2022 communication on preparedness and response69 and WHO's 2022 plan on strategic preparedness53—it is distinct from previous efforts22 given its design, which emphasized consensus building and the reporting of disagreement through the Delphi method, panellist diversity with regard to geography and disciplines, and the large sample size. The study's focus—ending COVID-19 as a public health threat—is defined as being evidenced by the resumption of pre-pandemic social, cultural, religious, political, healthcare, economic and educational activities in each country's context. Some retrospective matters (for example, pandemic root-cause analysis), theoretical questions and modelling were judged to be beyond the scope of the study.

Where possible, the study emphasizes recommendations that can be implemented in the short term (that is, in months, not years) to end COVID-19 as a public health threat. Although examples of countries implementing multiple recommendations exist (for example, free tests70, combining widespread testing and free treatment of positive cases along with digital technologies71, the development of vaccines providing long-lasting protection against variants72,73), the exceptions accentuate global challenges and provide new opportunities for action. Certain statements and recommendations resulting from this consensus process address gaps in WHO's strategic plan31, most strikingly, the failure to directly address the airborne nature of transmission. Initially, the WHO incorrectly labelled airborne transmission of SARS-CoV-2 as ‘misinformation’. Only much later, after multidisciplinary scientific efforts, did the WHO recognize airborne transmission to be a predominant mode of transmission74,75,76. By contrast, this panel recommends that ‘risk communications clearly emphasize’ (Table 6 (REC4.3)) the causal link between inhalation of SARS-CoV-2 and the transmission of COVID-19 as well as policy incentivizing ‘structural prevention measures (for example, ventilation, air filtration) to mitigate airborne transmission’ (Table 6 (REC4.1)).

The WHO's slow pace in directly addressing the airborne nature of transmission underscores why public health policy and risk communications should be based on evidence. For example, supposing that endemicity will result in lower virulence is an erroneous assumption77,78,79 that may exacerbate disproportionate risks of COVID-19 among vulnerable groups80. By extension, engagement with communities through effective risk communication should remain a priority for all countries.

The WHO recognizes the infodemic as a key challenge to effective communication for general populations53,81,82,83, vulnerable groups84 and scientists85. Governments, health authorities and healthcare providers should especially take care in the accuracy of their communications. The panel also emphasized that institutions should proactively monitor false health information and collaborate with trusted community leaders to refute it and enhance trust86.

Given the disproportionate impact that the pandemic has had on vulnerable groups to date87,88,89, the panel voiced concern that policy decisions must aim to find ways of lowering risk within these groups after resumption of the aforementioned activities (STMT6.1). As those vulnerable to COVID-19 in many countries can no longer rely on other individuals practising basic prevention measures (such as the use of face masks and isolating after testing positive), the structural changes recommended in this study (for example, indoor ventilation and filtration) assume heightened importance. Furthermore, COVID-19 continues to prompt global discussion and vigorous debate, particularly about tensions among medical ethics, civil liberties and pandemic control measures80. This study is no exception, with statements STMT1.6 (blaming unvaccinated individuals) and STMT3.2 (individual decisions regarding vaccination) receiving the highest levels of disagreement, underscoring the need for equitable structural interventions. In countries with widespread availability of vaccines, it is important for health authorities to distinguish between those who have clearly refused and are unlikely ever to seek vaccination and those who remain hesitant and continue to delay vaccination90. In the latter case, specific factors prolonging the delay can be addressed by targeted interventions. Finally, continued uncertainty about the widespread consequences of long COVID and its implications for public health policy (REC2.9) is an ongoing concern91,92.

Some innovations, notably vaccines37,38, have not been equitably distributed to low- and middle-income countries, and others, such as high-quality facemasks, have not been widely adopted in high-income countries despite their availability93. Some recommendations addressing pandemic inequities remain underleveraged; for example, providing more vaccines94 to countries with a low percentage of people vaccinated (REC6.10). Other recommendations may necessitate increased funding and time— for example, calls for continued vaccine and treatment innovations (REC2.12, REC5.2, REC5.6).

Importantly, the single significant difference in levels of panel agreement between those working in high-income countries and those working in low- and middle-income countries pertained to the role of economic incentives (REC3.6), probably reflective of sociocultural distinctions or perhaps disagreement over feasibility in implementation and ethics concerns95,96. Furthermore, 14% of the panellists considered themselves to be not qualified to respond to STMT4.3 concerning zoonotic variants, which probably indicates a lower understanding of biological vectors and the aetiology of variants among some of the disciplines included in the panel compared with the other topics covered97.

As noted above, the panellists nearly unanimously agreed on and prioritized whole-of-society and whole-of-government approaches98,99,100,101 (Table 8). The panellists also prioritized recommendations for communicating effectively with the public and developing technologies (for example, vaccines, therapies and services) that can reach target populations (Table 8). Failure to use these approaches risks not only prolonging COVID-19 as a public health threat, but also further diversion of resources from efforts to achieve other extant public health goals102,103.

One of the strengths of this study is its use of Delphi methodology. By demonstrating increased agreement with each subsequent round, this method enabled us to determine whether our incorporation of feedback was successful in refining the statements and recommendations, increasing the degree of consensus and, in some cases, reaching unanimity. The consistently increasing mean levels of agreement with the consensus statements and recommendations observed across all three survey rounds strengthens our confidence in the relevance of the iterative Delphi process in eliciting feedback to improve subsequent rounds. This is particularly noteworthy given that the effort to incorporate feedback from the expert panel may have resulted in more complex (for example, multiple item) statements and recommendations. Generally, there may be concerns as to the clarity of such statements; however, levels of agreement tended to be either maintained or increased, providing greater confidence in their resonance with the panel. The overall high response rates across three survey rounds speaks to both the rigorous implementation of the method and the commitment of the assembled panel of experts. Endorsement of the resultant consensus statements and recommendations by 184 organizations in 72 countries (Supplementary Table 2) at the time of publication further testifies to their global relevance.

Although the Delphi method is a robust approach (Methods) to assess levels of agreement on specific issues and explore whether a consensus can be reached, it is not without limitations. A main concern pertains to the construction of a truly representative expert panel. The sequential, multimethod sampling approach that we used (see the ‘Delphi expert panel member sample’ section in the Methods) minimized potential bias from purposive sampling of a small group and, instead, generated a large, geographically and disciplinarily diverse panel from multiple sources (that is, the core group, nominees from the core group and corresponding authors of key COVID-19 literature). While potential panellists were identified from their work related to COVID-19, infectious diseases, public health preparedness and other fields, the chairs further confirmed their appropriateness for the study by instructing them to not participate if they felt they lacked expertise concerning the pandemic. This approach appears to have been appropriate, as only 5–14% of the panellists felt they were not qualified to respond to just 5 out of the 41 statements, and 3 of the 57 recommendations. Although conducting the study in English limited the participation to English speakers, the inclusion of experts from 112 countries and territories strengthens our confidence in the potential broad applicability of these recommendations to a range of cultures and countries. With regard to the mid-study convening of the core group to discuss issues raised in the initial survey rounds, another limitation may have been that we conducted it virtually rather than in person (see the ‘Delphi data collection’ section in the Methods).

The multidisciplinary panel's emphasis on actionable, near-term recommendations guided the Delphi consensus-building process and increased the relevance of the study's findings to a broad group of stakeholders, including governments, public health authorities, NGOs, community-based organizations, industry, and social media platforms and other media. This consensus study advances a global vision of informed decision-making on how the world can end COVID-19 as a public health threat without a return to sweeping limitations on civil liberties, without risking the health and lives of vulnerable groups, and without exacerbating economic burdens.

We used an iterative sampling approach to generate a large panel for this Delphi study (Fig. 1). The four co-chairs (J.V.L., A.B., A.K. and A.E.-M.) identified a core group of 40 academic, health, NGO, government and policy experts from 25 countries and territories. Selection by the co-chairs was primarily based on publication record and engagement on COVID-19 issues as well as online biographies. Twenty-nine of these experts were well known to the chairs while seven were suggested through snowball sampling to result in geographical and gender equity among the core group of 40. Furthermore, a concerted effort was made towards multidisciplinary representation in the core group, including medical sciences (such as infectious diseases, public health and vaccinology), engineering, and social sciences (such as policy, law and ethics). The core group proposed additional experts to create a global panel of approximately 400 experts. The lead chair (J.V.L.) and methodologist (D.R.) led this core group through implementation of the project. Snowball sampling was then used as core group members identified individuals with expertise in COVID-19 from their professional networks to generate an initial list of potential Delphi panel members with the goal of broad representation. In proposing experts, co-chairs focused on identifying at least one representative from at least 100 countries. One co-chair (J.V.L.) took responsibility for reviewing the suggestions, with support from a research assistant who shared recent publications and a professional biography for every proposed co-author. Many initial suggestions were of leading experts with whom the co-chairs had previously collaborated.

The core group then reviewed the panel list for under-represented countries and PubMed/Medline searches were conducted using the search term ‘COVID-19’ in combination with the names of under-represented countries to identify authors of COVID-19 research studies involving primary data collection in these countries. Authors of relevant studies were invited to participate in the Delphi panel to further increase geographical diversity and include panellists beyond the core team members’ networks. All of the panel participants were carefully vetted; most had published in one or more relevant fields.

To further validate the expertise of the panel, the study was described to the invitees (n = 696) with the following instructions: "If you consider your professional training and expertise applicable to the subject matter of this global consensus statement project, we encourage you to participate in the panel." Informed consent was obtained for each panellist after explaining the purpose of the study and their expected contributions, including review and approval of the submitted manuscript, by accession to the Round 1 (R1) survey. Our objective was for invited participants to explicitly consider whether they had the necessary level of expertise before joining the Delphi panel. We do not have specific information regarding the basis of invitees’ non-participation but expect that these instructions enabled a substantial portion of non-respondents to self-select out of the study. We know that 84 invitees began the R1 survey but did not complete it; thus, if we assume that they did consider themselves to be eligible to participate but then decided not to do so, that would result in an estimated response rate of 82.1% (386 out of 470). The resultant expert panel is diverse in terms of demographic, disciplinary and geographical characteristics (Table 1).

The core group reviewed the published literature available up to January 2022 to draft initial statements for the first Delphi survey round, grouped in the following domains: (1) communication; (2) health systems; (3) vaccination; (4) prevention; (5) treatment and care; and (6) pandemic inequities. No formal systematic review with stringent criteria for levels of evidence was performed owing to the sheer volume of COVID-19-related published studies and the frequency at which they were and continue to be published. However, all of the authors and panellists were invited to suggest relevant papers, which were reviewed by the core group members based on journal rankings, paper citations and other metrics. In R1, panellists considered draft consensus statements based on the literature before moving to the next step of recommendations in round two (R2), which emanated from the panellists’ feedback on the statements as well as new research findings over the course of data collection from 18 February 2022 to 28 April 2022.

The study design consisted of digital data collection: two survey rounds (R1 and R2) of draft statements; an online consensus meeting of the core group (16 March 2022) to discuss salient issues; one round of draft recommendations (in R2); and, a final, third survey round (R3) of the consensus statements and recommendations (Fig. 1). The core group decided a priori to use a supermajority (that is, ≥67% combined agreement) minimum cut-off for consensus. This more demanding cut-off (relative to a simple majority of greater than 50%) was considered to be necessary given the project goal of supporting global policy and programmatic actions to address the COVID-19 public health crisis. We used the QualtricsXM platform to develop and distribute the surveys (round duration ranged from 1.5 to 3 weeks) with four-point Likert-type categories for measuring the level of agreement with the statements and recommendations (that is, agree, somewhat agree, somewhat disagree, disagree); a fifth ‘not qualified to respond’ option was provided given the panel's range of COVID-19 expertise. Panellists could provide comments and suggest edits to individual statements and recommendations in text boxes, which followed each of the statements and recommendations. All rounds allowed for overall comments at the end of the survey, and the researchers reviewed 1,409, 755, and 188 comments associated with the statements in R1, R2 and R3, respectively, and 1,025 and 2,156 comments associated with the recommendations in R2 and R3, respectively. Summaries of changes based on panellist input from a previous round were available in text boxes next to each statement and recommendation in the subsequent round. Similarly, the definition for "Ending COVID-19 as a public health threat as evidenced by the resumption of social, cultural, religious, political, healthcare, economic and educational activities in each country's context" was presented during each round so that panellists could respond to statements on the basis of a shared understanding of how the phrase "ending COVID-19 as a public health threat" was defined for the purpose of this study. In R3, panellists also ranked the top half of recommendations within each of the six domains, which were automatically randomized to mitigate order-effect bias. Using Microsoft Excel (v.16), scores were calculated and normalized using the Dowdall system to compare rankings across domains by accounting for weighting bias due to differences in the total number of recommendations in each domain137,138.

An important component of the data-collection process involves the discussion among core group members of issues that emerge from the early survey rounds and how best to incorporate such feedback in subsequent rounds. Given the geographical distribution of panel members and COVID-19-related travel and health concerns, we convened the core group virtually for in-depth, real-time deliberation. This web-based approach is different from in-person discussion of complicated or contentious issues; however, panel members had multiple opportunities to provide open-ended comments in the absence of dominant voices that can inhibit the expression of minority viewpoints during in-person convenings. Thus, the combination of real-time feedback (from core group members) and written feedback (from the entire panel) probably resulted in more comprehensive contributions overall.

Data analysis reflected the multiple-methods nature of Delphi studies and was managed by an analytic team of core group members, the study methodologist and research assistants. Across the three rounds, we ran frequencies of all statements and recommendations (Supplementary Discussion 2); the proportion who selected ‘not qualified to respond’ is reported in the data tables but removed from the denominator to calculate levels of agreement/disagreement from the relevant sample. The team then analysed the extensive qualitative data (that is, open-ended text-box comments). Specifically, comments were first reviewed individually by at least three core group members (J.V.L., co-chair; D.R., methodologist; and C.J.K.) and an additional co-author (T.M.W.). For each data collection round, comments were then discussed in online review meetings, including at least three core group members and an additional co-author. After review and discussion, comment suggestions were incorporated into statement and recommendation revisions for subsequent rounds. A supermajority of core group members (28 out of 40; 70%) participated in the online consensus meeting, which permitted in-depth breakout-group discussions on salient issues from R1 and R2 informing R3 revisions (Supplementary Discussion 3). Quantitative analysis of the final R3 results involved assigning each statement and recommendation a grade to indicate the level of combined agreement (agree + somewhat agree), using a system that has been used in other Delphi studies139,140,141 in which ‘U’ denotes unanimous (100%) agreement; ‘A’ denotes 90%–99% agreement; ‘B’ denotes 78%–89% agreement; and ‘C’ denotes 67%–77% agreement. Although all statements and recommendations exceeded the standard supermajority minimum of ≥67% combined agreement for consensus, we highlighted those with <67% for ‘agree’ alone for further analysis. Statements and recommendations were analysed using Fisher's exact tests in Stata (v.16) to assess differences in agreement by the following panellist characteristics: income level (high income versus low- and middle-income) for country of birth and country where currently working, primary sector of employment and primary field of employment (Supplementary Discussion 2). The use of the terms combined agreement and combined disagreement are presented in the results.

Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.

Additional data will be shared on request from the corresponding author for fair use.

Leppo, K., Ollila, E., Peña, S., Wismar, M. & Cook, S. Health in All Policies (Ministry of Social Affairs and Health, Finland, 2013).

Greenhalgh, T., Grifiin, S., Gurdasani, D. & Hamdy, A. COVID-19: an urgent call for global ‘vaccines-plus’ action. BMJ 376, o1 (2022).

Google Scholar

Lazarus, J. et al. COVID-SCORE: a global survey to assess public perceptions of government responses to COVID-19 (COVID-SCORE-10). PLoS ONE 15, e0240011 (2020).

Article CAS PubMed PubMed Central Google Scholar

Morens, D. M., Daszak, P., Markel, H. & Taubenberger, J. K. Pandemic COVID-19 joins history's pandemic legion. mBio 11, 3 (2020).

Article Google Scholar

Pandemic Fatigue: Reinvigorating the Public to Prevent COVID-19: Policy Framework for Supporting Pandemic Prevention and Management: Revised Version November 2020 (WHO, 2020); https://apps.who.int/iris/handle/10665/

COVID Live—Coronavirus Statistics (Worldometer, 2022); https://www.worldometers.info/coronavirus/#countries.

Adam, D. The pandemic's true death toll: millions more than official counts. Nature 601, 312–315 (2022).

Article CAS PubMed ADS Google Scholar

Wang, H. et al. Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21. Lancet 399, 1513–1536 (2022).

Article CAS Google Scholar

Kiss, P., Carcel, C., Hockham, C. & Peters, S. A. E. The impact of the COVID-19 pandemic on the care and management of patients with acute cardiovascular disease: a systematic review. Eur. Hear. J. Qual. Care Clin. Outcomes 7, 18–27 (2021).

Article Google Scholar

Alkatout, I. et al. Has COVID-19 affected cancer screening programs? A systematic review. Front. Oncol. 11, 1540 (2021).

Article Google Scholar

Murewanhema, G. & Makurumidze, R. Essential health services delivery in Zimbabwe during the COVID-19 pandemic: perspectives and recommendations. Pan Afr. Med. J. 35, 143 (2020).

Article PubMed PubMed Central Google Scholar

Shet, A. et al. Impact of the SARS-CoV-2 pandemic on routine immunisation services: evidence of disruption and recovery from 170 countries and territories. Lancet. Glob. Health 10, e186–e194 (2022).

Article PubMed Google Scholar

Chen, Z. et al. Global landscape of SARS-CoV-2 genomic surveillance and data sharing. Nat. Genet. 54, 499–507 (2022).

Article CAS PubMed PubMed Central Google Scholar

Malick, M. S. S. & Fernandes, H. The genomic landscape of severe acute respiratory syndrome coronavirus 2. Adv. Mol. Pathol. 4, 231–235 (2021).

Article CAS Google Scholar

Karthikeyan, S. et al. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Nature 609, 101–108 (2022).

Article CAS PubMed PubMed Central ADS Google Scholar

Coronavirus (COVID-19) Vaccinations. Statistics and Research https://ourworldindata.org/covid-vaccinations (Our World in Data, 2021).

Pérez-Alós, L. et al. Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors. Nat. Commun. 13, 1614 (2022).

Article PubMed PubMed Central ADS Google Scholar

Feikin, D. R. et al. Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression. Lancet 399, 924–944 (2022).

Article CAS PubMed PubMed Central Google Scholar

Lopez-Leon, S. et al. Long COVID in children and adolescents: a systematic review and meta-analyses. Sci. Rep. 12, 9950 (2022).

Article CAS PubMed PubMed Central ADS Google Scholar

Lopez-Leon, S. et al. More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Sci. Rep. 11, 16144 (2021).

Article CAS PubMed PubMed Central ADS Google Scholar

Subramanian, A. et al. Symptoms and risk factors for long COVID in non-hospitalized adults. Nat. Med. 28, 1706–1714 (2022).

Article CAS PubMed PubMed Central Google Scholar

Sachs, J. D. et al. The Lancet Commission on lessons for the future from the COVID-19 pandemic. Lancet 400, 1224–1280 (2022).

Global Trustworthiness Monitor https://www.ipsos.com/sites/default/files/ct/news/documents/2022-01/global-trustworthiness-monitor-2021-report_0.pdf (Ipsos, 2022).

Gentilini, U. et al. Social Protection and Jobs Responses to COVID-19: A Real-Time Review of Country Measures (World Bank, 2020).

Haleem, A., Javaid, M. & Vaishya, R. Effects of COVID-19 pandemic in daily life. Curr. Med. Res. Pract. 10, 78–79 (2020).

Article PubMed PubMed Central Google Scholar

Oliu-Barton, M. et al. SARS-CoV-2 elimination, not mitigation, creates best outcomes for health, the economy, and civil liberties. Lancet 397, 2234–2236 (2021).

Article CAS PubMed PubMed Central Google Scholar

Phillips, R. et al. Perceived threat of COVID-19, attitudes towards vaccination, and vaccine hesitancy: a prospective longitudinal study in the UK. Br. J. Health Psychol. 27, 1354–1381 (2022).

Servick, K. Is it time to live with COVID-19? Some scientists warn of ‘endemic delusion’. Science 375, 703–704 (2022).

Article CAS PubMed ADS Google Scholar

Mukaigawara, M. et al. An equitable roadmap for ending the COVID-19 pandemic. Nat. Med. 28, 893–896 (2022).

Article CAS PubMed Google Scholar

Schneider, K. R., Fanzo, J. C., Haddad, L. & Rosero Moncayo, J. A new strategy for health and sustainable development in the light of the COVID-19 pandemic. Lancet 398, 1029–1031 (2021).

Article Google Scholar

Bar-Yam, Y. et al. The World Health Network: a global citizens’ initiative. Lancet 398, 1567–1568 (2021).

Article CAS PubMed PubMed Central Google Scholar

van der Linden, S., Roozenbeek, J. & Compton, J. Inoculating against fake news about COVID-19. Front. Psychol. 11, 2928 (2020).

Google Scholar

Larson, H. J., Gakidou, E. & Murray, C. J. L. The vaccine-hesitant moment. N. Engl. J. Med. 387, 58–65 (2022).

Article CAS PubMed Google Scholar

Lazarus, J. V. et al. COVID-19 vaccine wastage in the midst of vaccine inequity: causes, types and practical steps. BMJ Glob. Health 7, e009010 (2022).

Article PubMed Google Scholar

COVID-19: Make it the Last Pandemic by The Independent Panel for Pandemic Preparedness & Response https://theindependentpanel.org/mainreport/ (The Independent Panel, 2021).

Batista, C. et al. The silent and dangerous inequity around access to COVID-19 testing: a call to action. EClinicalMedicine 43, 101230 (2022).

Article PubMed Google Scholar

Bayati, M., Noroozi, R., Ghanbari-Jahromi, M. & Jalali, F. S. Inequality in the distribution of Covid-19 vaccine: a systematic review. Int. J. Equity Health 21, 122 (2022).

Article PubMed PubMed Central Google Scholar

Lazarus, J. V. et al. Vaccinate fast but leave no one behind: a call to action for COVID-19 vaccination in Spain. Commun. Med. 1, 12 (2021).

Article PubMed PubMed Central Google Scholar

Pidiyar, V. et al. COVID-19 management landscape: a need for an affordable platform to manufacture safe and efficacious biotherapeutics and prophylactics for the developing countries. Vaccine 40, 5302–5312 (2022).

Article CAS PubMed PubMed Central Google Scholar

Public trust in scientists rose during the Covid-19 pandemic. Wellcome Global Monitor https://wellcome.org/news/public-trust-scientists-rose-during-covid-19-pandemic-0 (Wellcome, 2021).

Shanka, M. S. & Menebo, M. M. When and how trust in government leads to compliance towards COVID-19 precautionary measures. J. Bus. Res. 139, 1275–1283 (2021).

Article Google Scholar

Skjefte, M. et al. COVID-19 vaccine acceptance among pregnant women and mothers of young children: results of a survey in 16 countries. Eur. J. Epidemiol. 36, 197–211 (2021).

Article CAS PubMed PubMed Central Google Scholar

Lazarus, J. V. et al. A global survey of potential acceptance of a COVID-19 vaccine. Nat. Med. 27, 225–228 (2021).

Article CAS PubMed Google Scholar

Petherick, A. et al. A worldwide assessment of changes in adherence to COVID-19 protective behaviours and hypothesized pandemic fatigue. Nat. Hum. Behav. 5, 1145–1160 (2021).

Article PubMed Google Scholar

Third Round of the Global Pulse Survey on Continuity of Essential Health Services During the COVID-19 Pandemic https://www.who.int/publications/i/item/WHO-2019-nCoV-EHS_continuity-survey-2022.1 (WHO, 2022).

Gross, J. V., Mohren, J. & Erren, T. C. COVID-19 and healthcare workers: a rapid systematic review into risks and preventive measures. BMJ Open 11, 42270 (2021).

Article Google Scholar

Dzinamarira, T. et al. Risk factors for COVID-19 infection among healthcare workers. A first report from a living systematic review and meta-analysis. Saf. Health Work 13, 263–268 (2022).

Denning, M. et al. Determinants of burnout and other aspects of psychological well-being in healthcare workers during the COVID-19 pandemic: a multinational cross-sectional study. PLoS ONE 16, e0238666 (2021).

Article CAS PubMed PubMed Central Google Scholar

Watson, O. J. et al. Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infect. Dis. 22, 1293–1302 (2022).

Article CAS PubMed PubMed Central Google Scholar

Farina, M. & Lavazza, A. Advocating for greater inclusion of marginalized and forgotten populations in COVID19 vaccine rollouts. Int. J. Publ. Health 66, 1604036 (2021).

Article Google Scholar

Mawani, F. N. et al. COVID-19 economic response and recovery: a rapid scoping review. Int. J. Health Serv. 51, 247–260 (2021).

Article PubMed Google Scholar

Nguyen, A., Guttentag, A., Li, D. & Meijgaard, J. V. The impact of job and insurance loss on prescription drug use: a panel data approach to quantifying the health consequences of unemployment during the COVID-19 pandemic. Int. J. Health Serv. 52, 312–322 (2022).

Article PubMed PubMed Central Google Scholar

Strategic Preparedness, Readiness and Response Plan to end the Global COVID-19 Emergency in 2022 https://www.who.int/publications/i/item/WHO-WHE-SPP-2022.1 (WHO, 2022).

Edwards, A. M., Baric, R. S., Saphire, E. O. & Ulmer, J. B. Stopping pandemics before they start: lessons learned from SARS-CoV-2. Science 375, 1133–1139 (2022).

Article CAS PubMed ADS Google Scholar

Haldane, V. et al. Health systems resilience in managing the COVID-19 pandemic: lessons from 28 countries. Nat. Med. 27, 964–980 (2021).

Article CAS PubMed Google Scholar

Pramesh, C. S. et al. Choosing wisely for COVID-19: ten evidence-based recommendations for patients and physicians. Nat. Med. 27, 1324–1327 (2021).

Article CAS PubMed Google Scholar

Linas, B. P. et al. Projecting COVID-19 mortality as states relax nonpharmacologic interventions. JAMA Health Forum 3, e220760 (2022).

Article PubMed PubMed Central Google Scholar

Tam, K. M., Walker, N. & Moreno, J. Influence of state reopening policies in COVID-19 mortality. Sci. Rep. 12, 1677 (2022).

Article CAS PubMed PubMed Central ADS Google Scholar

Greer, S. L., King, E. J., da Fonseca, E. M. & Peralta-Santos, A. The comparative politics of COVID-19: the need to understand government responses. Glob. Publ. Health 15, 1413–1416 (2020).

Article Google Scholar

Bollyky, T. J. et al. Pandemic preparedness and COVID-19: an exploratory analysis of infection and fatality rates, and contextual factors associated with preparedness in 177 countries, from Jan 1, 2020, to Sept 30, 2021. Lancet 399, 1489–1512 (2022).

Article Google Scholar

Tang, J. W. et al. An exploration of the political, social, economic and cultural factors affecting how different global regions initially reacted to the COVID-19 pandemic. Interface Focus 12, 20210079 (2022).

Article PubMed PubMed Central Google Scholar

Zheng, C. et al. Real-world effectiveness of COVID-19 vaccines: a literature review and meta-analysis. Int. J. Infect. Dis. 114, 252–260 (2022).

Article CAS PubMed Google Scholar

Burn, E. et al. Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study. Lancet Infect. Dis. 22, 1142–1152 (2022).

Article CAS PubMed PubMed Central Google Scholar

Health at a Glance https://www.oecd-ilibrary.org/sites/ae3016b9-en/index.html?itemId=/content/publication/ae3016b9-en (OECD, 2021).

Islam, N. et al. Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries. BMJ 373, n1137 (2021).

Article PubMed Google Scholar

Clarke, J. M., Majeed, A. & Beaney, T. Measuring the impact of COVID-19. BMJ 375, e066952 (2021).

Strasser, Z., Hadavand, A., Shawn, M. & Estiri, H. SARS-CoV-2 Omicron variant is as deadly as previous waves after adjusting for vaccinations, demographics, and comorbidities. Preprint at Research Square https://doi.org/10.21203/rs.3.rs-1601788/v1 (2022).

Mefsin, Y. M. et al. Epidemiology of infections with SARS-CoV-2 Omicron BA.2 variant, Hong Kong, January–March 2022. Emerg. Infect. Dis. 28, 1856–1858 (2022).

Directorate-General for Health and Food Safety. COVID-19—Sustaining EU Preparedness and Response: Looking Ahead https://health.ec.europa.eu/publications/covid-19-sustaining-eu-preparedness-and-response-looking-ahead-0_en (European Commission, 2022).

Rader, B. et al. Use of at-home COVID-19 tests—United States, August 23, 2021–March 12, 2022. MMWR 71, 489–494 (2022).

CAS PubMed PubMed Central Google Scholar

Lee, D., Heo, K. & Seo, Y. COVID-19 in South Korea: lessons for developing countries. World Dev. 135, 105057 (2020).

Article PubMed PubMed Central Google Scholar

Wang, C. Y. et al. A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants. J. Clin. Invest. 132, e157707 (2022).

Article CAS PubMed PubMed Central Google Scholar

Afkhami, S. et al. Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2. Cell 185, 896–915 (2022).

Article CAS PubMed PubMed Central Google Scholar

WHO. Fact Check: COVID-19 is Not Airborne https://twitter.com/WHO/status/1243972193169616898?ref_src=twsrc%5Etfw (Twitter, 2020).

Lewis, D. Why the WHO took two years to say COVID is airborne. Nature 604, 26–31 (2022).

Article CAS PubMed ADS Google Scholar

Telenti, A. et al. After the pandemic: perspectives on the future trajectory of COVID-19. Nature 596, 495–504 (2021).

Article CAS PubMed ADS Google Scholar

Greenhalgh, T., Ozbilgin, M. & Tomlinson, D. How COVID-19 spreads: narratives, counter narratives, and social dramas. BMJ 378, e069940 (2022).

Article Google Scholar

Antia, R. & Halloran, M. E. Transition to endemicity: Understanding COVID-19. Immunity 54, 2172–2176 (2021).

Article CAS PubMed PubMed Central Google Scholar

Whitaker, M. et al. Variant-specific symptoms of COVID-19 among 1,542,510 people in England. Preprint at medRxiv https://doi.org/10.1101/2022.05.21.22275368 (2022)

Gostin, L. O., Friedman, E. A. & Wetter, S. A. Responding to COVID-19: how to navigate a public health emergency legally and ethically. Hastings Cent. Rep. 50, 8–12 (2020).

Article PubMed PubMed Central Google Scholar

Wang, Y., McKee, M., Torbica, A. & Stuckler, D. Systematic literature review on the spread of health-related misinformation on social media. Soc. Sci. Med. 240, 112552 (2019).

Article PubMed PubMed Central Google Scholar

Islam, M. S. et al. COVID-19-related infodemic and its impact on public health: a global social media analysis. Am. J. Trop. Med. Hyg. 103, 1621–1629 (2020).

Article CAS PubMed PubMed Central Google Scholar

Purnat, T. Delivering actionable infodemic insights and recommendations for the COVID-19 pandemic response. WER 27, 313–324 (2021).

Google Scholar

Choukou, M. A. et al. COVID-19 infodemic and digital health literacy in vulnerable populations: a scoping review. Digit. Health 8, 20552076221076927 (2022).

PubMed PubMed Central Google Scholar

Palayew, A. et al. Pandemic publishing poses a new COVID-19 challenge. Nat. Hum. Behav. 4, 666–669 (2020).

Article PubMed Google Scholar

Vaccination and Trust: How Concerns Arise and the Role of Communication in Mitigating Crises (WHO, 2017).

Shadmi, E. et al. Health equity and COVID-19: global perspectives. Int. J. Equity Health 19, 104 (2020).

Article PubMed PubMed Central Google Scholar

Lebrasseur, A. et al. Impact of COVID-19 on people with physical disabilities: a rapid review. Disabil. Health J. 14, 101014 (2021).

Article PubMed Google Scholar

Kumar, N. et al. Sexual health (excluding reproductive health, intimate partner violence and gender-based violence) and COVID-19: a scoping review. Sex. Transm. Infect. 97, 402–410 (2021).

Article PubMed Google Scholar

Lazarus, J. V. et al. Revisiting COVID-19 vaccine hesitancy around the world using data from 23 countries in 2021. Nat. Commun. 13, 3801 (2022).

Article CAS PubMed PubMed Central ADS Google Scholar

Al-Aly, Z., Bowe, B. & Xie, Y. Long COVID after breakthrough SARS-CoV-2 infection. Nat. Med. 28, 1461–1467 (2022).

Article CAS PubMed PubMed Central Google Scholar

A Clinical Case Definition of Post COVID-19 Condition by a Delphi Consensus, 6 October 2021 https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1 (WHO, 2021).

Li, H. et al. Efficacy and practice of facemask use in general population: a systematic review and meta-analysis. Transl. Psychiatry 2022, 49 (2022).

Article Google Scholar

Yamey, G. et al. It is not too late to achieve global covid-19 vaccine equity. BMJ 376, e070650 (2022).

Article PubMed PubMed Central Google Scholar

Jarrett, C. et al. Strategies for addressing vaccine hesitancy—a systematic review. Vaccine 33, 4180–4190 (2015).

Article PubMed Google Scholar

Persad, G. & Emanuel, E. J. Ethical considerations of offering benefits to COVID-19 vaccine recipients. JAMA 326, 221–222 (2021).

Article CAS PubMed Google Scholar

Vora, N. M. et al. Want to prevent pandemics? Stop spillovers. Nature 605, 419–422 (2022).

Article CAS PubMed ADS Google Scholar

Chiriboga, D., Garay, J., Buss, P., Madrigal, R. S. & Rispel, L. C. Health inequity during the COVID-19 pandemic: a cry for ethical global leadership. Lancet 395, 1690–1691 (2020).

Article CAS PubMed PubMed Central Google Scholar

Wenham, C. What went wrong in the global governance of COVID-19? Brit. Med. J. 372, n303 (2021).

Article PubMed Google Scholar

Global Preparedness Monitoring Board. From Worlds Apart to a World Prepared (WHO, 2021).

Sirleaf, R., Johnson, H. E. E. & Clark, H. H. Transforming or Tinkering? Inaction Lays the Groundwork for Another Pandemic (The Independent Panel for Pandemic Preparedness and Response, 2022).

Shulla, K. et al. Effects of COVID-19 on the Sustainable Development Goals (SDGs). Discov. Sustain. 2, 15 (2021).

Article PubMed PubMed Central Google Scholar

The Sustainable Development Goals Report 2021 https://unstats.un.org/sdgs/report/2021/ (UN, 2021).

Tracking SARS-CoV-2 variants https://www.who.int/activities/tracking-SARS-CoV-2-variants (WHO, 2022).

Chandler, J. C. et al. SARS-CoV-2 exposure in wild white-tailed deer (Odocoileus virginianus). Proc. Natl Acad. Sci. USA 118, e2114828118 (2021).

Nesteruk, I. Influence of possible natural and artificial collective immunity on new COVID-19 pandemic waves in Ukraine and Israel. Explor. Res. Hypothesis Med. 7, 8–18 (2022).

Article Google Scholar

Taquet, M. et al. Incidence, co-occurrence, and evolution of long-COVID features: a 6-month retrospective cohort study of 273,618 survivors of COVID-19. PLoS Med. 18, e1003773 (2021).

Article CAS PubMed PubMed Central Google Scholar

Carson, G. et al. Research priorities for long COVID: refined through an international multi-stakeholder forum. BMC Med. 19, 84 (2021).

Article CAS PubMed PubMed Central Google Scholar

Buonsenso, D. et al. Preliminary evidence on long COVID in children. Acta Paediatr. 110, 2208–2211 (2021).

Article CAS PubMed PubMed Central Google Scholar

Crook, H., Raza, S., Nowell, J., Young, M. & Edison, P. Long COVID—mechanisms, risk factors, and management. BMJ 374, n1648 (2021).

Article PubMed Google Scholar

Khan, K. et al. Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection. Nat. Commun. 13, 4686 (2022)

Noh, J. Y., Jeong, H. W. & Shin, E. C. SARS-CoV-2 mutations, vaccines, and immunity: implication of variants of concern. Signal Transduct. Target. Ther. 6, 203 (2021).

Article CAS PubMed PubMed Central Google Scholar

Tian, D., Sun, Y. H., Zhou, J. M. & Ye, Q. The global epidemic of SARS-CoV-2 variants and their mutational immune escape. J. Med. Virol. 94, 847–857 (2022).

Article CAS PubMed Google Scholar

Goldberg, Y. et al. Waning immunity after the BNT162b2 vaccine in Israel. N. Engl. J. Med. 385, e85 (2021).

Article CAS PubMed Google Scholar

Ssentongo, P. et al. SARS-CoV-2 vaccine effectiveness against infection, symptomatic and severe COVID-19: a systematic review and meta-analysis. BMC Infect. Dis. 22, 439 (2022).

Article CAS PubMed PubMed Central Google Scholar

Global Dashboard for Vaccine Equity https://data.undp.org/vaccine-equity/ (UNDP Data Futures Platform, 2022).

MacDonald, N. E. et al. Vaccine hesitancy: definition, scope and determinants. Vaccine 33, 4161–4164 (2015).

Article PubMed Google Scholar

El-Mohandes, A. et al. COVID-19 vaccine acceptance among adults in four major US metropolitan areas and nationwide. Sci. Rep. 11, 21844 (2021).

Article CAS PubMed PubMed Central ADS Google Scholar

Duan, Y. et al. Disparities in COVID-19 vaccination among low-, middle-, and high-income countries: the mediating role of vaccination policy. Vaccines 9, 905 (2021).

Article CAS PubMed PubMed Central Google Scholar

Sabahelzain, M. M., Hartigan-Go, K. & Larson, H. J. The politics of COVID-19 vaccine confidence. Curr. Opin. Immunol. 71, 92–96 (2021).

Article CAS PubMed PubMed Central Google Scholar

Meng, H., Mao, J. & Ye, Q. Booster vaccination strategy: necessity, immunization objectives, immunization strategy, and safety. J. Med. Virol. 94, 2369–2375 (2022).

Article CAS PubMed Google Scholar

Brandon, Ng,T. S., Leblanc, K., Yeung, D. F. & Tsang, T. S. M. Medication use during COVID-19: review of recent evidence. Can. Fam. Physician 67, 171–179 (2021).

Article Google Scholar

Chou, R., Dana, T. & Jungbauer, R. Update alert 8: masks for prevention of respiratory virus infections, including SARS-CoV-2, in health care and community settings. Ann. Intern. Med. 175, W108–W109 (2022).

Article PubMed Google Scholar

Kuhfeldt, K. et al. Examination of SARS-CoV-2 in-class transmission at a large urban university with public health mandates using epidemiological and genomic methodology. JAMA Netw. Open 5, e2225430 (2022).

Article PubMed PubMed Central Google Scholar

Samaan, G. et al. The World Health Organization's actions within the United Nations system to facilitate a whole-of-society response to COVID-19 at country level. Front. Publ. Health. 9, 831220 (2022).

Article Google Scholar

Bump, J. B., Friberg, P. & Harper, D. R. International collaboration and COVID-19: what are we doing and where are we going? BMJ 372, n180 (2021).

Article PubMed PubMed Central Google Scholar

Tanveer, S., Rowhani-Farid, A., Hong, K., Jefferson, T. & Doshi, P. Transparency of COVID-19 vaccine trials: decisions without data. BMJ Evid. Based Med. 27, 199–205 (2021).

Article PubMed Google Scholar

Moosavi, J., Fathollahi-Fard, A. M. & Dulebenets, M. A. Supply chain disruption during the COVID-19 pandemic: recognizing potential disruption management strategies. Int. J. Disaster Risk Reduct. 75, 102983 (2022).

Article PubMed PubMed Central Google Scholar

Purnat, T. D., Wilson, H., Nguyen, T. & Briand, S. EARS—a WHO platform for AI-supported real-time online social listening of COVID-19 conversations. Stud. Health Technol. Inform. 281, 1009–1010 (2021).

PubMed Google Scholar

Wu, E.-L. et al. Disparities in COVID-19 monoclonal antibody delivery: a retrospective cohort study. J. Gen. Intern. Med. 37, 2505–2513 (2022).

Article PubMed PubMed Central Google Scholar

Mølhave, M., Agergaard, J. & Wejse, C. Clinical management of COVID-19 patients—an update. Semin. Nucl. Med. 52, 4–10 (2022).

Article PubMed Google Scholar

No-One is Safe Until Everyone is Safe—Why We Need a Global Response to COVID-19 https://www.unhcr.org/news/press/2021/5/60a7fc9b4/statement-no-one-safe-safe-need-global-response-covid-19.html (UNHCR, 2021).

Marra, A. R. et al. Short-term effectiveness of COVID-19 vaccines in immunocompromised patients: a systematic literature review and meta-analysis. J. Infect. 84, 297–310 (2022).

Article CAS PubMed PubMed Central Google Scholar

Orben, A., Tomova, L. & Blakemore, S. J. The effects of social deprivation on adolescent development and mental health. Lancet Child Adolesc. Health 4, 634–640 (2020).

Article CAS PubMed PubMed Central Google Scholar

Paris, C. et al. Risk factors for SARS-CoV-2 infection among health care workers. Am. J. Infect. Control 50, 375–382 (2022).

Article PubMed Google Scholar

Cahill, A. G. et al. Occupational risk factors and mental health among frontline health care workers in a large US metropolitan area during the COVID-19 pandemic. Prim. Care Companion CNS Disord. 24, 40038 (2022).

Article Google Scholar

Reilly, B. Social choice in the south seas: electoral innovation and the Borda count in the Pacific Island countries. Int. Polit. Sci. Rev. 23, 355–372 (2016).

Article Google Scholar

Fraenkel, J. & Grofman, B. The Borda count and its real-world alternatives: comparing scoring rules in Nauru and Slovenia. Aust. J. Polit. Sci. 49, 186–205 (2014).

Article Google Scholar

Rubino, F. et al. Joint international consensus statement for ending stigma of obesity. Nat. Med. 26, 485–497 (2020).

Article CAS PubMed PubMed Central Google Scholar

Lazarus, J. V. et al. Advancing the global public health agenda for NAFLD: a consensus statement. Nat. Rev. Gastroenterol. Hepatol. 19, 60–78 (2021).

Article PubMed Google Scholar

Lazarus, J. V. et al. Consensus statement on the role of health systems in advancing the long-term well-being of people living with HIV. Nat. Commun. 12, 4450 (2021).

Article CAS PubMed PubMed Central ADS Google Scholar

Download references

The chairs and core author group thank all of the panellists who completed the surveys, including for their thousands of helpful comments. They specifically thank the few panellists who are not co-authors but did actively participate in the survey rounds: K. Adolf, N. Alwan, I. Araújo, M. Brookman-Amissah, C. Caceres, M. Childs, S. Duckett, F. Farzadfar, A. Glassman, H. Hopkins, M. Kall, M. Paule Kieny, M. Malebona Precious, K. Prather, V. Priesemann, P. Ananth Tambyah, K. Yaw and S. Zhan. They further thank ISGlobal research assistants L. van Selm, C. Pujol Martínez and R. Freiheit for support, and L. Ansley Hobbs (CUNY SPH) for technical support with the QualtricsXM platform. J.V.L., Q.B., A.L.G.-B., G.F., M.K., D.N., R.V. and T.M.W. acknowledge support to ISGlobal from the Spanish Ministry of Science, Innovation and Universities through the "Centro de Excelencia Severo Ochoa 2019–2023" Programme (CEX2018-000806-S), and from the Government of Catalonia, Spain, through the CERCA Programme. J.S. acknowledges support from J. Waller for his contributions. No funding was received for this manuscript. We thank Wilton Park for hosting and sponsoring the virtual consensus meeting on 16 March 2022.

Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain

Jeffrey V. Lazarus, Quique Bassat, Gonzalo Fanjul, Alberto L. Garcia-Basteiro, Manolis Kogevinas, Denise Naniche, Rafael Vilasanjuan & Trenton M. White

Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain

Jeffrey V. Lazarus

City University of New York Graduate School of Public Health and Health Policy (CUNY SPH), New York City, NY, USA

Jeffrey V. Lazarus, Diana Romero, Kenneth Rabin, Ayman El-Mohandes & Scott Ratzan

Independent Researcher, Sioux Falls, SD, USA

Christopher J. Kopka

University of KwaZulu-Natal, Durban, South Africa

Salim Abdool Karim

Centre for the AIDS Program of Research in South Africa (CAPRISA), Durban, South Africa

Salim Abdool Karim

Weill Cornell Medicine, Cornell University, Ithaca, NY, USA

Laith J. Abu-Raddad

Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, Doha, Qatar

Laith J. Abu-Raddad

Pan American Health Organisation, Washington, DC, USA

Gisele Almeida & Ernesto Bascolo

UNITE Global Parliamentarians Network, Lisbon, Portugal

Ricardo Baptista-Leite

Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands

Ricardo Baptista-Leite

Institute of Health Sciences (CIIS), Catholic University of Portugal, Lisbon, Portugal

Ricardo Baptista-Leite

University of Colorado School of Medicine, Aurora, CO, USA

Joshua A. Barocas & Jay Lemery

Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil

Mauricio L. Barreto, Mauricio Barreto, Tania Araujo-Jorge, Fernando A. Bozza, Ligia Giovanella & Marcus V. Lacerda

University of Bahia, Salvador, Brazil

Mauricio L. Barreto, Mauricio Barreto & Luis Eugenio de Souza

New England Complex Systems Institute, Cambridge, MA, USA

Yaneer Bar-Yam & Gunhild Alvik Nyborg

Manhiça Health Research Center (CISM), Maputo, Mozambique

Quique Bassat & Pedro Aide

Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain

Quique Bassat

Pediatrics Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain

Quique Bassat

Biomedical Research Consortium in Epidemiology and Public Health (CIBERESP), Madrid, Spain

Quique Bassat

Doctors Without Borders (MSF), Geneva, Switzerland

Carolina Batista, Tammam Aloudat, Renata Reis & Renata Santos

Baraka Impact Finance, Geneva, Switzerland

Carolina Batista

Payne Institute, Colorado School of Mines, Golden, CO, USA

Morgan Bazilian

National Yang Ming Chiao Tung University, Taipei, Taiwan

Shu-Ti Chiou

Emory School of Medicine, Atlanta, GA, USA

Carlos del Rio & Carlos del Rio

University of New South Wales (UNSW) Sydney, Sydney, New South Wales, Australia

Gregory J. Dore, C. Raina MacIntyre, Guy B. Marks & Faye McMillan

Chinese Center for Disease Control and Prevention, Beijing, China

George F. Gao

The O’Neill Institute for National and Global Health Law, Georgetown University, Washington, DC, USA

Lawrence O. Gostin, Ngozi A. Erondu & Rebecca Katz

Burnet Institute, Melbourne, Victoria, Australia

Margaret Hellard & Leanne Robinson

Department of Chemistry, University of Colorado Boulder, Boulder, CO, USA

Jose L. Jimenez

Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado Boulder, Boulder, CO, USA

Jose L. Jimenez

Christian Medical College (CMC), Vellore, India

Gagandeep Kang

Wilton Park, Steyning, UK

Nancy Lee

Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre, Ljubljana, Slovenia

Mojca Matičič

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Mojca Matičič

The London School of Hygiene & Tropical Medicine, London, UK

Martin McKee

University Teaching Hospital of Butare, Butare, Rwanda

Sabin Nsanzimana

Paris Dauphine University - PSL, Paris, France

Miquel Oliu-Barton

French National Centre for Scientific Research (CNRS), Grenoble, France

Bary Pradelski

University College London (UCL), London, UK

Oksana Pyzik, Rochelle Burgess, Susan Michie, Christina Pagel & Robert West

Dr. Rajendra Prasad Government Medical College, Himachal Pradesh, India

Sunil Raina & Dinesh Kumar

James P. Grant School of Public Health, BRAC University, Dhaka, Bangladesh

Sabina Faiz Rashid

Plenitud Foundation, Santo Domingo, Dominican Republic

Magdalena Rathe & Laura Rathe

University of Costa Rica, San José, Costa Rica

Rocio Saenz, Henriette Raventos, Carolina Santamaria-Ulloa & Juan Rafael Vargas

Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

Sudhvir Singh & Chris Bullen

Independent Philosopher, Copenhagen, Denmark

Malene Trock-Hempler

Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA

Sonia Villapol

International Digital Health & AI Research Collaborative (I-DAIR), Geneva, Switzerland

Peiling Yap & Amandeep Singh Gill

University of Global Health Equity, Kigali, Rwanda

Agnes Binagwaho & Judy Khanyola

University of Malaya, Kuala Lumpur, Malaysia

Adeeba Kamarulzaman & Sanjay Rampal

Ifakara Health Institute, Dar es Salaam, Tanzania

Salim Abdulla

University of Ottawa, Ottawa, Ontario, Canada

Sarah Addleman & Jennifer McDonald

Baku Health Centre, Baku, Azerbaijan

Gulnara Aghayeva

The University of Manchester, Manchester, UK

Raymond Agius

Mogadishu University, Mogadishu, Somalia

Mohammed Ahmed

Generations for Health, Madrid, Spain

Mohamed Ahmed Ramy

Karolinska University Hospital, Stockholm, Sweden

Soo Aleman & Anders Vahlne

Ministry of Health and Population, Port-au-Prince, Haiti

Jean-Patrick Alfred

Moi University, Eldoret, Kenya

Shamim Ali

Hurlingham National University, Hurlingham, Argentina

Jorge Aliaga

Graduate Institute of International and Development Studies, Geneva, Switzerland

Sarah L. M. Davis

King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

Saleh A. Alqahtani

Salmaniya Medical Complex, Manama, Bahrain

Jameela Al-Salman

Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

John H. Amuasi

Trivedi School of Biosciences, Ashoka University, Sonepat, India

Anurag Agrawal

Community Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Wagida Anwar

Faculty of Health and Social Sciences, University of The Americas, Santiago, Chile

Osvaldo Artaza

University of Alberta, Edmonton, Alberta, Canada

Leyla Asadi

University of Health and Allied Sciences, Ho, Volta, Ghana

Yaw Awuku & Davidson Iroko

University of Otago, Wellington, New Zealand

Michael Baker & Amanda Kvalsvig

University of Sao Paulo, Sao Paulo, Brazil

Lorena Barberia & Deisy Ventura

European Public Health Alliance, Brussels, Belgium

Paul Belcher & Milka Sokolović

Ministry of Health and Wellness Belize, Belmopan, Belize

Lizett Bell

Aids Healthcare Foundation, São Paulo, Brazil

Adele Benzaken

Department of Physics, Stockholm University, Stockholm, Sweden

Emil Bergholtz

Boston University Center for Emerging Infectious Diseases Policy and Research (CEID), Boston, MA, USA

Nahid Bhadelia

Centre For Ethics, Yenepoya University, Mangaluru, India

Anant Bhan

Smart Phases, Plattsburgh, NY, USA

Stephane Bilodeau

Bitran y Asociados, Santiago, Chile

Ricardo Bitrán

Delft University of Technology, Delft, The Netherlands

Philomena Bluyssen

Transmissible, Houten, The Netherlands

Arnold Bosman

Institute of Genetics, Technische Universität Braunschweig, Braunschweig, Germany

Melanie M. Brinkmann

Management Sciences for Health, Medford, MA, USA

Andrew Brown

University of the Witwatersrand, Johannesburg, South Africa

Bruce Mellado & Helen Rees

Kenya Medical Research Institute, Nairobi, Kenya

Elizabeth Bukusi, Eleanor Ochodo & Benjamin Tsofa

University of Cassino and Southern Lazio, Cassino, Italy

Giorgio Buonanno

King's College London, London, UK

Matthew Butler

Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda

Pauline Byakika-Kibwika & Bruce J. Kirenga

Universidad del Desarrollo, Santiago, Chile

Baltica Cabieses

The Global Fund, Geneva, Switzerland

Gunilla Carlsson

Catholic University of the Sacred Heart, Rome, Italy

Fidelia Cascini & Walter Ricciardi

University of Zambia, Lusaka, Zambia

Chishala Chabala & Choolwe Jacobs

Fattouma Bourguiba Teaching Hospital, Monastir, Tunisia

Mohamed Chakroun

Institute of Applied Health Research, University of Birmingham, Birmingham, UK

K. K. Cheng

Ministry of Health Seychelles, Victoria, Seychelles

Agnes Chetty

National Aerospace University "Kharkiv Aviation Institute", Kharkiv, Ukraine

Dmytro Chumachenko

Yale School of Public Health, New Haven, CT, USA

Gregg Consalves

University of Cambridge, Cambridge, UK

Andrew Conway Morris

Cairo University Hospitals, Cairo, Egypt

Ahmed Cordie & Rahma Mohamed

Africa Research Excellence Fund (AREF), London, UK

Tumani Corrah

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Brenda Crabtree-Ramírez

Onom Foundation, Ulaanbaatar, Mongolia

Naranjargal Dashdorj

Ben Gurion University of the Negev, Be’er Sheva, Israel

Nadav Davidovitch & Dorit Nitzan

National Centre for Disease Control and National Vector Borne Disease Control Programme, Government of India, Delhi, India

Akshay Chand Dhariwal

University of Bucharest, Bucharest, Romania

Elena Druică & Marian-Gabriel Hâncean

Koç University İşbank Center for Infectious Diseases, Istanbul, Turkey

Onder Ergonul

Kabul University of Medical Sciences, Kabul, Afghanistan

Mohammad Yasir Essar

University of Gothenburg, Gothenburg, Sweden

Andrew Ewing & Jan Löttvall

CONICET/National University of Tres de Febrero, Caseros, Argentina

Daniel Feierstein

Federation of American Scientists, Washington, DC, USA

Eric Feigl-Ding

Social Security Board, Belize City, Belize

Ramon Figueroa

The University of the West Indies, Kingston, Jamaica

John Peter Figueroa

National University of Singapore, Singapore, Singapore

Dale Fisher, Siyan Yi & Yik-Ying Teo

Center for the Study of Equity and Governance in Health Systems, Guatemala City, Guatemala

Walter Flores

Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela

David A. Forero-Peña

Department of Health Metrics Sciences, University of Washington, Seattle, WA, USA

Howard Frumkin, Simon I. Hay & Ali H. Mokdad

National Center for Disease Control and Public Health of Georgia, Tbilisi, Georgia

Amiran Gamkrelidze & Natia Skhvitaridze

UCSF, San Francisco, CA, USA

Monica Gandhi & Jaime Sepulveda

School of Public Health, Cayetano Heredia University, Lima, Peru

Patricia Garcia

Icahn School of Medicine at Mount Sinai, New York City, NY, USA

Adolfo García-Sastre

MAMC & Associated Hospitals New Delhi, New Delhi, India

Suneela Garg

University of Lomé, Lomé, Togo

F. A. Gbeasor-Komlanvi

Universidad Nacional Autonoma de Mexico, Mexico City, Mexico

Carlos Gershenson

Organised Medicine Academic Guild—OMAG, Mumbai, India

Ishwar Gilada

Simon Bolivar University, Caracas, Venezuela

Marino González

University of Haifa, Haifa, Israel

Manfred S. Green

University of Oxford, Oxford, UK

Trisha Greenhalgh & Aris Katzourakis

University of Queensland, Brisbane, Queensland, Australia

Paul Griffin

University of Leeds, Leeds, UK

Stephen Griffin

National Institute of Infectology Evandro Chagas-Fiocruz, Rio de Janeiro, Brazil

Beatriz Grinsztejn

Indian Council of Medical Research, New Delhi, India

Tanu Anand

National Institute of Public Health, Cuernavaca, Mexico

Germán Guerra

St Luke's Medical Center College of Medicine, Quezon City, The Philippines

Renzo Guinto

Department of Public Health, Medical University of Warsaw, Warsaw, Poland

Mariusz Gujski

Ankara City Hospital Infectious Diseases and Clinical Mirobiology, Ankara, Turkey

Rahmet Guner

Independent Researcher, Port Louis, Mauritius

Adam Hamdy

Ministry of Health, Colombo, Sri Lanka

Abusayeed Haniffa

Ateneo School of Government, Quezon City, The Philippines

Kenneth Y. Hartigan-Go

Independent Consultant, Cairo, Egypt

Hoda K. Hassan

University of Helsinki, Helsinki, Finland

Matti T. J. Heino

University of Alabama at Birmingham, Birmingham, AL, USA

Zdenek Hel & Jeanne Marrazzo

National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA

Peter Hotez

19 To Zero, Calgary, Alberta, Canada

Jia Hu

Center for Disease Control and Geohealth Studies, Academy of Sciences and Arts of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina

Mirsada Hukić

COHRED, Geneva, Switzerland

Carel IJsselmuiden

Independent Consultant, Cairo, Egypt

Maged Iskarous

International Center for Research on Women, Washington, DC, USA

Chimaraoke Izugbara

Centre for Digital Therapeutics, Toronto, Ontario, Canada

Alejandro R. Jadad

Aga Khan University, Karachi, Pakistan

Fyezah Jehan

NYU Grossman School of Medicine, New York City, NY, USA

Ayana Jordan

School of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco

Imane Jroundi

University of Toronto, Toronto, Ontario, Canada

Kevin Kain & C. David Naylor

Research Centre of Public Health, Faculty of Health, University of Vlore "Ismail Qemali" Albania, Vlorë, Albania

Fatjona Kamberi & Enkeleint Mechili

Gamaleya National Research Center for Epidemiology and Microbiology of the Ministry of Health of the Russian Federation, Moscow, Russian Federation

Eduard Karamov

Division of Infectious Disease & Geographic Medicine, Stanford University, Stanford, CA, USA

Abraar Karan

Kamuzu University of Health Sciences, Blantyre, Malawi

Abigail Kazembe

Royal Hospital, Ministry of Health, Muscat, Oman

Faryal Khamis & Julian Tang

Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan

Komiljon Khamzayev

University of Leicester, Leicester, UK

Kamlesh Khunti

African Center for Global Health and Social Transformation, Kampala, Uganda

Elsie Kiguli-Malwadde

Division of Infectious Diseases, Guro Hospital, College of Medicine Korea University, Seoul, Republic of Korea

Woo Joo Kim

Comenius University in Bratislava, Bratislava, Slovakia

Daniel Klimovský

Syracuse University, Syracuse, NY, USA

Brittany L. Kmush

University of Miami Institute for Advanced Study of the Americas, Coral Gables, FL, USA

Felicia Knaul

Coalition of Epidemic Preparedness Innovations (CEPI), Oslo, Norway

Frederik Kristensen

Institute of Family Medicine and Primary Care, Greater Noida, India

Raman Kumar

London School of Economics & Political Science, London, UK

Arush Lal

Bradford Institute for Health Research & Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK

Tom Lawton

St Georges University of London, London, UK

Anthony J. Leonardi

The University of Hong Kong, Hong Kong, China

Yuguo Li

University Ziane Achour Djelfa, Djelfa, Algeria

Mohamed Lounis

University of Buenos Aires/Health Systems Global, Buenos Aires, Argentina

Daniel Maceira

Faculty of Social and Human Sciences, Khemis-Miliana University, Khemis Miliana, Algeria

Azzeddine Madani

National and Kapodistrian University of Athens, Athens, Greece

Gkikas Magiorkinis, Georgios Papatheodoridis, Dimitrios Paraskevis, Vana Sypsa & Sotirios Tsiodras

Digestive Disease Research Institute Tehran University of Medical Sciences, Tehran, Iran

Reza Malekzadeh

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK

Marc Choisy

University of Nebraska Medical Center, Omaha, NE, USA

Jasmine R. Marcelin

Virginia Tech, Blacksburg, VA, USA

Linsey Marr

University of Cabo Verde, Praia, Cape Verde

Antonieta Martina

Department of Preventive Medicine and Public Health and INCLIVA, University of Valencia, Valencia, Spain

José M. Martín-Moreno

Instituto #SaludsinBulos, Madrid, Spain

Carlos Mateos

University of Health Sciences, Ministry of Health, Vientiane, Lao People's Democratic Republic

Mayfong Mayxay

Foundation for Innovative New Diagnostics, Geneva, Switzerland

Jean Bapiste Mazarati

Institute of Health Research Epidemiological Surveillance and Trainings (IRESSEF), Dakar, Senegal

Souleymane Mboup

Universal Health Monitor, Bethesda, MD, USA

Andre Medici

University of Glasgow, Glasgow, UK

Petra Meier

King Saud Medical City, Ministry of Health and College of Medicine Alfaisal University, Riyadh, Saudi Arabia

Ziad A. Memish

Amrita Institute of Medical Sciences, Kochi, India

Jaideep Menon

International Food Policy Research Institute, New Delhi, India

Purnima Menon

Goldman Hine LLP, Toronto, Ontario, Canada

Jonathan Mesiano-Crookston

Department of Gastroeterology, University Hospital Center Riejka, Riejka, Croatia

Ivana Mikolasevic

School of Medicine, University of Belgrade, Belgrade, Serbia

Ognjen Milicevic

MaREI Centre, Ryan Institute & School of Engineering, University of Galway, Galway, Ireland

Asit Kumar Mishra

University of Saskatchewan, Saskatoon, Saskatchewan, Canada

Michele Monroy-Valle

Queensland University of Technolgy, Brisbane, Queensland, Australia

Lidia Morawska

Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle, UK

Sterghios A. Moschos

Faculty of Medicine, Alexandria University, Alexandria, Egypt

Karam Motawea

New York State Department of Health, Albany, NY, USA

Sayed Hamid Mousavi & Jaffer Shah

American University of Beirut, Beirut, Lebanon

Ghina Mumtaz & Nesrine Rizk

Faith to Action Network, Nairobi, Kenya

Peter K. Munene

International University of Catalonia, Barcelona, Spain

Carmen Muñoz Almagro

IntraHealth International, Nairobi, Kenya

Janet Muriuki

African Population and Health Research Center, Nairobi, Kenya

Sylvia Muyingo

Africa Centers for Disease Control and Prevention (Africa CDC), Addis Ababa, Ethiopia

Nicaise Ndembi

Masaryk University, Brno, Czech Republic

Juraj Nemec

Institute of Hydromechanics, National Academy of Sciences of Ukraine, Kiev, Ukraine

Igor Nesteruk

Yale School of Medicine, New Haven, CT, USA

Christine Ngaruiya & Sandra A. Springer

International Livestock Research Institute, Nairobi, Kenya

Hung Nguyen

University Clinic of Gastroenterohepatology, Faculty of Medicine, University "Ss. Cyril and Methodius", Skopje, Republic of Macedonia

Dafina Nikolova

University of Bergen, Bergen, Norway

Ole Norheim

College of Dentistry, Dar Al Uloom University, Riyadh, Saudi Arabia

Mohammed Noushad

Congolese Foundation for Medical Research, Brazzaville, Republic of the Congo

Francine Ntoumi

Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

Francine Ntoumi

Covid Action Group, World Health Network, Son, Norway

Gunhild Alvik Nyborg

Department of Infectious Diseases, Internal Medicine, School of Medicine, Marmara University, Istanbul, Turkey

Zekaver Odabasi

Effective Basic Services (eBASE) Africa, Bamenda, Cameroon

Mbah Patrick Okwen

University of Geneva, Institute of Global Health, Geneva, Switzerland

Keiser Olivia

Franciscus Gasthuis en Vlietland, Rotterdam, The Netherlands

David S. Y. Ong

Wayne State University School of Medicine, Detroit, MI, USA

Ijeoma Opara

International Independent Expert on Health Systems, Managua, Nicaragua

Miguel Orozco

Tohoku University Graduate School of Medicine, Sendai, Japan

Hitoshi Oshitani

McGill School of Population and Global Health, Montreal, Quebec, Canada

Madhukar Pai

Training for Health Equity Network: THEnet, New York City, NY, USA

Björg Pálsdóttir

Dalhousie University, Halifax, Nova Scotia, Canada

Jeanna Parsons Leigh

Drugs for Neglected Diseases initiative, Geneva, Switzerland

Bernard Pécoul

ifo Institute at the University of Munich, Munich, Germany

Andreas Peichl

Two Oceans in Health, Santo Domingo, Dominican Republic

Eddy Perez-Then

Vietnam One Health University Network (VOHUN), Hanoi University of Public Health (HUPH), Hanoi, Vietnam

Phuc Pham Duc

Molinari Economic Institute, Paris, France

Cécile Philippe

CIMA, UMI-IFAECI/CNRS, FCEyN, Universidad de Buenos Aires-UBA/CONICET, Buenos Aires, Argentina

Andrea Pineda Rojas

National Health Care for the Homeless Council, Nashville, TN, USA

Courtney Pladsen

Chelsea and Westminster Hospital, London, UK

Anton Pozniak

INFIQC-CONICET, National University of Córdoba, Córdoba, Argentina

Rodrigo Quiroga

Department of Botany, University of Chakwal, Chakwal, Pakistan

Huma Qureshi

Brown University, Providence, RI, USA

Megan Ranney

Institute for Global Health and Development, Bissau, Guinea-Bissau

Magda Robalo

NHS Greater Glasgow and Clyde, Glasgow, UK

Eleanor Robertson

Erasmus University Medical Center, Rotterdam, The Netherlands

Casper Rokx

Africa Europe Foundation, Brussels, Belgium

Tamsin Ros

Norwegian Institute of Public Health, Oslo, Norway

John-Arne Røttingen

Kohelet Policy Forum, Jerusalem, Israel

Meir Rubin

Chulalongkorn University, Bangkok, Thailand

Kiat Ruxrungtam & Poovorawan Yong

Research Institute of Virology under the Ministry of Health of Uzbekistan, Tashkent, Uzbekistan

Shakhlo Sadirova

Child Health Research Foundation, Dhaka, Bangladesh

Senjuti Saha

National Institute of Public Health, Mexico City, Mexico

Nelly Salgado

Center of Molecular Immunology, La Havana, Cuba

Lizet Sanchez

University of Maryland, College Park, MD, USA

Thurka Sangaramoorthy

Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar

Bisher Sawaf

Technical University of Dortmund, Dortmund, Germany

Matthias F. Schneider

University of California San Diego, San Diego, CA, USA

Robert T. Schooley & Steffanie Strathdee

Infectious Disease Department, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey

Alper Sener

Faculty of Medicine, Syrian Private University, Damascus, Syrian Arab Republic

Mosa Shibani

Department of Psychiatry, Jawahar Lal Nehru Memorial Hospital, Srinagar, India

Sheikh Shoib

Centre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia

Izukanji Sikazwe

The Office of the Government of the Republic of Lithuania, Vilnius, Lithuania

Aistis Šimaitis

CORE Group Polio Project India, Delhi, India

Roma Solomon

Independent Consultant, Quito, Ecuador

Xavier Solórzano

Institute of Experimental Psychology, Centre of Social and Psychological Sciences, Slovak Academy of Sciences, Bratislava, Slovakia

Jakub Šrol

Dublin City University, Dublin, Ireland

Anthony Staines

University of Calgary, Calgary, Alberta, Canada

Henry T. Stelfox & Joe Vipond

Institute for Research, Development and Innovation, International Medical University, Kuala Lumpur, Malaysia

Lokman Hakim Sulaiman

Department of Health, Melbourne, Victoria, Australia

Brett Sutton

Norwegian University of Science and Technology, Trondheim, Norway

Dag Svanæs

Faculty of Medicine, Aleppo University, Aleppo, Syrian Arab Republic

Sarya Swed

Global Health Literacy Academy, Risskov, Denmark

Kristine Sørensen

African Union, Addis Ababa, Ethiopia

Raji Tajudeen

University of British Columbia, Vancouver, British Columbia, Canada

Amy Tan

Swiss Academies of Arts and Sciences, Bern, Switzerland

Marcel Tanner

Indraprastha Institute of Information Technology, Delhi, India

Tavpritesh Sethi

Centre of Excellence in Women and Child Health, Aga Khan University, Nairobi, Kenya

Marleen Temmerman

Burnet Institute Myanmar, Yangon, Myanmar

Kyu Kyu Than

Institute for Health Sciences Research (CNRST/IRSS), Nanoro, Burkina Faso

Halidou Tinto

People's Health Movement, Abomey-Calavi, Benin

Sênoudé Pacôme Tomètissi

Fundacion Octaedro, Quito, Ecuador

Irene Torres

Khesar Gyalpo University of Medical Sciences of Bhutan, Thimphu, Bhutan

K. P. Tshering

Antioquia University, Medellin, Colombia

Ivan Dario Velez Bernal

Mälardalens University, Mälardalens, Sweden

Sarah Wamala-Andersson

Technical University of Denmark, Kongens Lyngby, Denmark

Pawel Wargocki

University of Michigan Medical School, Ann Arbor, MI, USA

Angela Weyand

Hospital Clínic, University of Barcelona, Barcelona, Spain

Trenton M. White

Bruegel Free University of Brussels, Brussels, Belgium

Guntram Wolff

College of Environmental Sciences and Engineering, Peking University, Beijing, China

Maosheng Yao

University of Bath, Bath, UK

Christian A. Yates

African Forum for Research and Education in Health, Kumasi, Ghana

Georgina Yeboah

National Centre for Infectious Diseases, Singapore, Singapore

Leo Yee-Sin

Gobierna Consulting Firm, Lima, Peru

Victor Zamora-Mesía

Department of Infectious Diseases, Odense University Hospital, Odense, Denmark

Anne Øvrehus

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

This study was led by four co-chairs (J.V.L., A.B., A.K. and A.E.-M.) who were part of a core group of 40 co-authors (J.V.L., D.R., C.J.K., S.A.K., L.J.A.R., G.A., R.B.L., J.A.B., M.L.B., Y.B.-Y., Q.B., C.B., M.B., S.-T.C., C.d.R., G.J.D., G.G., L.O.G., M.H., J.L.J., C.K., N.L., M.M., M.M.K., S.N., M.O.B., B.P., O.P., K.R., S.R., S.R., M.R., R.S., S.S., M.T.-H., S.V., P.Y., A.B., A.K. and A.E.-M.). The co-chairs regularly updated the core group members by email and J.V.L. led an online consensus meeting hosted by Wilton Park in March 2022. D.R., the lead chair (J.V.L.) and T.M.W. led the methodology. J.V.L., D.R., T.M.W. and C.J.K. reviewed all comments submitted as part of the three survey rounds. J.V.L., C.J.K. and T.M.W. reviewed all comments sent directly by email. J.V.L., D.R., C.J.K., T.M.W. and K.R. reviewed all comments from the peer reviewers. All COVID-19 Consensus Statement Panel members had the opportunity to review the full draft of the manuscript and provide three rounds of comments through QualtricsXM. Those fulfilling authorship criteria are named (n = 364).

Correspondence to Jeffrey V. Lazarus.

J.V.L. reports research grants to his institution from AbbVie, Gilead Sciences and MSD, and speaker fees from AbbVie, Gilead Sciences, Intercept, Janssen, MSD and ViiV, and an advisory board fee from AbbVie and Novavax, all unrelated to this work. R.A. is a co-chair of the Occupational Medicine Committee of the British Medical Association and a member of the Industrial Injuries Advisory Council (UK). S.A. reports honoraria for lectures and educational events from Gilead, AbbVie, MSD and Biogen, and reports grants, not related to COVID-19, from Gilead and AbbVie. The A.G.-S. laboratory has received research support from Pfizer, Senhwa Biosciences, Kenall Manufacturing, Avimex, Johnson & Johnson, Dynavax, 7Hills Pharma, Pharmamar, ImmunityBio, Accurius, Nanocomposix, Hexamer, N-fold, Model Medicines, Atea Pharma, Applied Biological Laboratories and Merck. A.G.-S. has consulting agreements for the following companies involving cash and/or stock: Vivaldi Biosciences, Contrafect, 7Hills Pharma, Avimex, Vaxalto, Pagoda, Accurius, Esperovax, Farmak, Applied Biological Laboratories, Pharmamar, Paratus, CureLab Oncology, CureLab Veterinary, Synairgen and Pfizer. A.G.-S. has been an invited speaker in meeting events organized by Seqirus, Janssen and AstraZeneca. A.G.-S. is listed as an inventor on patents and patent applications (US patent numbers: 5,820,871; 5,854,037; 6,001,634; 6,146,642; 6,451,323; 6,468,544; 6,544,785; 6,573,079; 6,635,416; 6,649,372; 6,669,943; 6,740,519; 6,852,522; 6,866,853; 6,884,414; 6,887,699; 7,060,430; 7,384,774; 7,442,379; 7,494, 808; 7,588,768; 7,833,774; 8,012,490; 8,057,803; 8,124,101; 8,137,676; 8,591,881; 8,629,283; 8,673,314; 8,709,442; 8,709,730; 8,765,139; 8,828,406; 8,999,352; 9,051,359; 9,096,585; 9,175,069; 9,217,136; 9,217,157; 9,238,851; 9,352,033; 9,371,366; 9,387,240; 9,387,242; 9,549,975; 9,701,723; 9,708,373; 9,849,172; 9,908,930; 9,968,670; 10,035,984; 10,098,945; 10,131,695; 10,137,189; 10,179,806; 10,251,922; 10,308,913; 10,543,268; 10,544,207; 10,583,188; 10,736,956; 11,254,733; and 11,266,734) on the use of antivirals and vaccines for the treatment and prevention of virus infections and cancer, owned by the Icahn School of Medicine at Mount Sinai, New York. S.G. reports being a member of Independent SAGE and member of the Pfizer Antivirals Advisory Board. P.H. reports being co-inventor of a COVID-19 recombinant protein vaccine technology owned by the Baylor College of Medicine (BCM) that was recently licenced by BCM non-exclusively and with no patent restrictions to several companies committed to advance vaccines for low- and middle-income countries. The co-inventors have no involvement in licence negotiations conducted by the BCM. Similar to other research universities, a long-standing BCM policy provides its faculty and staff, who make discoveries that result in a commercial licence, a share of any royalty income. To date, BCM has not distributed any royalty income to the co-inventors on the COVID-19 recombinant protein vaccine technology. Any such distribution will be undertaken in accordance with BCM policy. A.K. has served as a paid consultant to the Independent Panel on Pandemic Preparedness and Response in 2020–21. K.K. is Chair of the Ethnicity Subgroup of the UK Scientific Advisory Group for Emergencies (SAGE) and Member of SAGE. J.L. reports owning equity in Codiak BioSciences and Exocure Biosciences, both having developed experimental COVID-19 vaccines. G.M. reports honoraria for a presentation from Novartis and consulting fees from AstraZeneca. S.M. reports being founder and chief scientific officer of PulmoBioMed. T.S. serves as the scientific director of the O’Brien Institute for Public Health and reports funding from the Canadian Institutes of Health Research. V.S. is a member of the National Scientific Committee of Experts for COVID-19 in Greece and reports grants from Gilead and Abbvie that are not related to this work or to COVID-19 research. A.T. reports grants from the Foundation for Advancing Family Medicine Janus Research Grant; Canadian Frailty Network Research Grant, Speaking Honoraria: University of Ottawa, McMaster University, Northern Ontario School of Medicine, McGill University, University of Calgary, BC Bereavement Hotline, Early Education Teachers of Ontario-Yok Region Union, Ontario Council for Cooperation, TELUS Science World-Vancouver. R.B. has been COVID-19 adviser to UK government and acts as a senior scientific adviser for a communications company working for the UK Government on COVID-19. A.W. reports research funding from Pfizer (unrelated to COVID-19) and a consulting fee from Ocugen. K.Y. is an unpaid member of the Independent SAGE group of scientists. The other authors declare no competing interests.

Nature thanks Jeremy Farrar, Sean Grant and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

In the third and final round of the Delphi process, panel members were asked to rank the recommendations per domain (n = 6) based on importance. This figure shows the top half of the recommendations for each of the six domains (communication; health systems; vaccination; prevention; treatment and care; and inequities).

Expert panel online meeting: "Ending COVID-19 as a public health threat: consensus statement". This file contains the minutes of the expert panel online meeting between the second and the third round of the Delphi process.

Supplementary Discussions 1 and 2, with additional results. These quantitative results provide a broader understanding of the results presented in the main paper. Supplementary Discussion 1 contains quantitative results of agreement on statements and recommendations. Supplementary Discussion 2 contains results of bivariate analyses of the statements and recommendations by panellist characteristics.

The quantitative results for statements presented in rounds 1 and 2 of the Delphi process and for recommendations presented in round 2 along with a brief description of changes between rounds.

Institutions endorsing the statements and recommendations of ‘A multinational Delphi consensus to end the COVID-19 public health threat’.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

Lazarus, J.V., Romero, D., Kopka, C.J. et al. A multinational Delphi consensus to end the COVID-19 public health threat. Nature 611, 332–345 (2022). https://doi.org/10.1038/s41586-022-05398-2

Download citation

Received: 19 May 2022

Accepted: 29 September 2022

Published: 03 November 2022

Issue Date: 10 November 2022

DOI: https://doi.org/10.1038/s41586-022-05398-2

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

npj Vaccines (2023)

Nature Medicine (2023)

Nature Medicine (2023)

Nature Reviews Microbiology (2023)

Nature Medicine (2023)

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.